Patients in Focus: What’s Relevant for Chronic Myeloid Leukaemia and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukaemia?
This satellite symposium took place on 22nd June 2017 as part of the 22nd European Hematology Association (EHA) Congress in Madrid, Spain
Chairperson: Michele Baccarani1
Co-chair: Eduardo Olavarria2
Speakers: Hugues de Lavallade,3 Delphine Rea,4 Giovanni Martinelli1
1. University of Bologna, Bologna, Italy
2. Imperial College London, London, UK
3. King’s College Hospital, London, UK
4. Saint-Louis Hospital, Paris, France
Disclosure: Prof Michele Baccarani received honoraria from ARIAD*/Incyte, Bristol-Myers Squibb, Novartis, and Pfizer. Dr Eduardo Olavarria has declared no conflicts of interest. Dr Hugues de Lavallade received honoraria from Bristol-Myers Squibb, Novartis, and Pfizer, and received research grant support from ARIAD*/Incyte and Bristol-Myers Squibb. Dr Delphine Rea received honoraria from ARIAD*/Incyte, Bristol-Myers Squibb, Novartis, and Pfizer. Dr Giovanni Martinelli received research support from Novartis, Bristol-Myers Squibb, Amgen, Pfizer, Genzyme, Celgene, Roche, Incyte, ARIAD*, Jansen, Cell Play, European Commission (EC) Harmony, EC Innovative Medicines Initiative 2, Fondazione del Monte di Ravenna e Bologna, CarisBo, AIRC, and AIL, and received honoraria from Novartis, Bristol-Myers Squibb, Amgen, Pfizer, AIRC, AIL, Genzyme, Celgene, ARIAD*, and Roche, and took part in speaker bureaux sponsored by Novartis, Bristol-Myers Squibb, Amgen, Pfizer, AIRC, AIL, Genzyme, Celgene, ARIAD*, and Roche. He has received honoraria from Novartis, Bristol-Myers Squibb, Amgen, Pfizer, AIRC, AIL, Genzyme, Celgene, ARIAD*, GlaxoSmithKline, Takeda, and Millennium.
*Now acquired by Takeda.
Acknowledgements: Writing assistance was provided by Sarah Etheridge, ApotheCom, London, UK.
Support: The publication of this article was funded by Incyte Biosciences International. The views and opinions expressed are those of the authors and not necessarily those of Incyte Biosciences International.
Citation: EMJ Hematol. 2017;5:53-61.
This symposium was dedicated to discussing BCR-ABL-positive chronic myeloid leukaemia (CML) and Philadelphia-positive acute lymphoblastic leukaemia (Ph+ALL). Prof Baccarani opened the symposium, highlighting the recent improvements in survival in patients with BCR-ABL-positive CML and Ph+ALL. Dr de Lavallade discussed the role of mutational analyses as part of molecular monitoring, including the use of next-generation sequencing (NGS) to assess BCR-ABL mutation status and to detect low-frequency mutations. Dr Rea reviewed treatment options for CML with tyrosine kinase inhibitors (TKI) in the second and third-line treatment settings. The session concluded with Dr Martinelli presenting mutational burden in Ph+ALL patients and treatment options for these patients, in particular, with ponatinib, emphasising the importance of early treatment initiation.
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