Double-Hit and Triple-Hit Lymphomas: New Perspectives for Their Classification

  • Home / Double-Hit and Triple-Hit Lymphomas: New Perspectives for Their Classification

Double-Hit and Triple-Hit Lymphomas: New Perspectives for Their Classification

*Cristiano Claudino Oliveira, Maria Aparecida Custódio Domingues

Department of Pathology, Botucatu School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
*Correspondence to cristiano_c_oliveira@hotmail.com

Disclosure: The authors have declared no conflicts of interest.
Received: 10.03.17 Accepted: 10.07.17
Citation: EMJ Hematol. 2017;5[1]:95-103.

Abstract

In 2016, an update on the classification of lymphoid neoplasm was published, and one of the modifications made focussed on B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt’s lymphoma, a term which has now been abandoned. This represented a very difficult disease in the diagnostic routine of pathologists. The new proposed term is high-grade B-cell lymphoma, which includes the double-hit lymphomas. Yet, there was still confusion about the diagnostic criteria. This review discusses the changes in classification, with an emphasis on the double-hit lymphomas. Diffuse large B-cell lymphoma and Burkitt’s lymphoma are also commented on in the text. The diagnosis of double-hit lymphomas is dependent on molecular tests and it is not available throughout the world. Research identifying features that can allow patients to be specifically selected for these molecular tests is also important.

This article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

The post Double-Hit and Triple-Hit Lymphomas: New Perspectives for Their Classification appeared first on European Medical Journal.

About Post Author

Medical CPD & News

The Digitalis CPD trawler searches the web for all the latest news and journals.

Privacy Preference Center

Close your account?

Your account will be closed and all data will be permanently deleted and cannot be recovered. Are you sure?

Are you sure?

By disagreeing you will no longer have access to our site and will be logged out.